Comparison of the therapeutic effects of promethazine and ephedrine stability of Hemodynamic patients undergoing arthroplasty with cement consumption

Introduction: In arthroplasty, spinal anesthesia was preferred to general anesthesia for a variety of reasons due to the use of cement. the side effects of cement on the cardiovascular system of patients, which can be catastrophic, it,s necessary to find appropriate treatment methods to reduce side effects of cement. method: In this clinical trial, 90 patients were arthroplasty candidates divided into three groups. The first group 25 mg intravenous promethazine, the second 10 mg intravenous ephedrine and the control group the equivalent volume of distilled intravenous water 10 minutes before cement injection received. Hemodynamic symptoms of patients entering the operating room, after spinal, immediately before injection. The drug was recorded after injection, five and ten minutes after cement injection. Data analysis by descriptive and inferential levels. Results:  promethazine and ephedrine and control groups in systolic blood pressure at the time after drug injection and five and ten minutes after cement and diastolic blood pressure at 10 minutes after cement were significant(p<0.05). There was a significant difference between the study groups in heart rate at five minutes after cementing (p = 0.041) and also in terms of O2 SAT at time of arrival (p = 0.001). Conclusion: According to the results of the study, in patients with arthroplasty by injection of cement due to hemodynamic changes, the use of ephedrine and promethazine can affect the hemodynamic stability of patients and help stabilize systolic blood pressure (ephedrine) and diastolic blood pressure and heart rate (promethazine) To minimize the complications of these surgeries